癌变·畸变·突变 ›› 1999, Vol. 11 ›› Issue (1): 11-013.doi: 10.3969/j.issn.1004-616x.1999.01.004

• 论著 • 上一篇    下一篇

五加皮的体内抗诱变性研究

刘　冰1 　庞慧民1 　陈敏怡2   

  1. 1 白求恩医科大学医学遗传学教研室　长春　130021 　2上海第二医科大学附属新华医院
  • 收稿日期:1998-04-06 修回日期:1998-08-04 出版日期:1999-01-30 发布日期:1999-01-30

STUDY ON THE ANTIMUTAGENIC EFFECT IN VIVO OF CORTEX ACANTHOPANASIA RADICIS

Liu Bing1, Pang Huimin1, Chen Minyi2   

  1. 1 Department of Medical Genetics, Norman Bathune University of Medical Sciences, ChangChun 　130021 　2 Shanghai Second Medical University, A ttached XinHua Hospital
  • Received:1998-04-06 Revised:1998-08-04 Online:1999-01-30 Published:1999-01-30

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摘要： 本文采用小鼠骨髓嗜多染红细胞微核试验和小鼠精子畸形试验,探讨中药五加皮的体内抗诱变作用。结果表明,五加皮各剂量(1g/ kg ,2g/ kg ,4g/ kg) 对MMC 诱发的微核率和精子畸形率均有明显的拮抗作用( P < 0. 01) ,微核抑制率达50.5 % - 73. 27 % ,精子畸形抑制率高达73. 45 % - 84 %。结果提示,五加皮具有拮抗MMC 诱发的体细胞和生殖细胞遗传损伤的作用。

关键词: 五加皮, 丝裂霉素C, 微核试验, 精子畸形

Abstract: The antimutagenic effect of Cortex acanthopanasia Radicis (CAR) has been studied by mean of micronucleus test of mouse bone marrow polychromatic erythrocyte ( PCE) and mouse spermatid malformation test . The result s indicated that chinese medicine CAR it self has no genotoxic effect . The inhibition rates of CAR (1g/ kg ,2g/ kg ,4g/ kg) to micronuclei was respectively 73. 27 % ,50. 5 % and 63. 37 % ( P < 0. 01) ,and inhibition rates of CAR to spermatid malformation was 84 % (1g/ kg) , 81. 45 %(2g/ kg) and 73. 45 % (4g/ kg) ( P <0. 01) . It is suggested that CAR can significantly inhibit the genetic damage of germ cells and stomatic cells induced by MMC.

Key words: Cortex acanthopanasia radicis, mitomycin C(MMC), micronucleus test, sperm aberration

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